Isolation, Characterization,
and NO Inhibitory Activities
of Sesquiterpenes from Blumea balsamifera
Jing Xu
Da-qing Jin
Cuizhou Liu
Chunfeng Xie
Yuanqiang Guo
Lingzhi Fang
10.1021/jf302530u.s001
https://acs.figshare.com/articles/journal_contribution/Isolation_Characterization_and_NO_Inhibitory_Activities_of_Sesquiterpenes_from_Blumea_balsamifera/2496391
Blumea balsamifera belongs
to the
family Compositae, and its leaves have been used as a flavoring ingredient
and a tea. A phytochemical investigation of the aerial parts of B. balsamifera led to the isolation of 10 new (<b>1</b>–<b>10</b>) and 1 known (<b>11</b>) sesquiterpenes.
Their structures were elucidated on the basis of extensive one- and
two-dimensional nuclear magnetic resonance (heteronuclear multiple-quantum
coherence, heteronuclear multiple-bond correlation, <sup>1</sup>H–<sup>1</sup>H correlation spectroscopy, and nuclear Overhauser effect
spectrometry) spectroscopic data analyses, and the structure of compound <b>1</b> was confirmed by X-ray crystallography. The inhibitory activities
on lipopolysaccharide-induced NO production in murine microglial BV-2
cells of these sesquiterpenes were evaluated, and all of the compounds
showed inhibitory effects.
2016-02-20 14:38:15
compound 1
BV
crystallography
heteronuclear
basis
spectroscopic data analyses
Blumea balsamiferaBlumea balsamifera
coherence
family Compositae
Isolation
phytochemical investigation
Sesquiterpene
Inhibitory Activities
microglial
Characterization
isolation
sesquiterpene
flavoring ingredient
spectroscopy
correlation
murine
resonance
Overhauser effect spectrometry