Isolation, Characterization, and NO Inhibitory Activities of Sesquiterpenes from Blumea balsamifera Jing Xu Da-qing Jin Cuizhou Liu Chunfeng Xie Yuanqiang Guo Lingzhi Fang 10.1021/jf302530u.s001 https://acs.figshare.com/articles/journal_contribution/Isolation_Characterization_and_NO_Inhibitory_Activities_of_Sesquiterpenes_from_Blumea_balsamifera/2496391 Blumea balsamifera belongs to the family Compositae, and its leaves have been used as a flavoring ingredient and a tea. A phytochemical investigation of the aerial parts of B. balsamifera led to the isolation of 10 new (<b>1</b>–<b>10</b>) and 1 known (<b>11</b>) sesquiterpenes. Their structures were elucidated on the basis of extensive one- and two-dimensional nuclear magnetic resonance (heteronuclear multiple-quantum coherence, heteronuclear multiple-bond correlation, <sup>1</sup>H–<sup>1</sup>H correlation spectroscopy, and nuclear Overhauser effect spectrometry) spectroscopic data analyses, and the structure of compound <b>1</b> was confirmed by X-ray crystallography. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these sesquiterpenes were evaluated, and all of the compounds showed inhibitory effects. 2016-02-20 14:38:15 compound 1 BV crystallography heteronuclear basis spectroscopic data analyses Blumea balsamiferaBlumea balsamifera coherence family Compositae Isolation phytochemical investigation Sesquiterpene Inhibitory Activities microglial Characterization isolation sesquiterpene flavoring ingredient spectroscopy correlation murine resonance Overhauser effect spectrometry