%0 Journal Article
%A Li, Ting
%A Ni, Siyang
%A Jia, Changhong
%A Wang, Hongyuan
%A Sun, Guizhi
%A Wu, Linzhuan
%A Gan, Maoluo
%A Shan, Guangzhi
%A He, Weiqing
%A Lin, Ling
%A Zhou, Hongxia
%A Wang, Yiguang
%D 2012
%T Identification of 4,5-Dihydro-4-hydroxygeldanamycins
As Shunt Products of Geldanamycin Biosynthesis
%U https://acs.figshare.com/articles/journal_contribution/Identification_of_4_5_Dihydro_4_hydroxygeldanamycins_As_Shunt_Products_of_Geldanamycin_Biosynthesis/2493313
%R 10.1021/np3001738.s001
%2 https://acs.figshare.com/ndownloader/files/4136176
%K GDM biosynthesis
%K Streptomyces hygroscopicus 17997. Compounds 1
%K cytochrome P 450 oxidase
%X Two new geldanamycin (GDM) analogues, (4S)-4,5-dihydro-4-hydroxygeldanamycin
(1) and (4R)-4,5-dihydro-4-hydroxygeldanamycin
(2), were identified from Streptomyces hygroscopicus 17997. Compounds 1 and 2 were not normal
intermediates of GDM biosynthesis but shunt products of C-4,5 oxidation
catalyzed by GdmP, a cytochrome P450 oxidase acting as a desaturase
in GDM biosynthesis. Preliminary assays implied that, compared with
GDM, 1 and 2 exhibited decreased cytotoxicity.
%I ACS Publications