10.1021/cg300727r.s007 Rafel Prohens Rafel Prohens Anna Portell Anna Portell Xavier Alcobé Xavier Alcobé Effect of Preorganization on the Polymorphism and Cocrystallization of a Squaramide Compound American Chemical Society 2016 intramolecular hydrogen bond laboratory cocrystal crystal structures polymorph strategy CompoundA supramolecular synthons Preorganization Polymorphism ability preorganization compound Cocrystallization data polymorphism Squaramide diffraction resorcinol cocrystallization model 2016-02-20 12:46:57 Dataset https://acs.figshare.com/articles/dataset/Effect_of_Preorganization_on_the_Polymorphism_and_Cocrystallization_of_a_Squaramide_Compound/2490565 A squaramido-based model compound with the ability to establish an intramolecular hydrogen bond has been designed to study the effect of preorganization on its polymorphism and the cocrystallization with resorcinol. Three out of the four expected supramolecular synthons have been observed in two polymorphs and two cocrystals with resorcinol, whose crystal structures have been solved from X-ray diffraction laboratory data using direct-space strategies.