Cobalt(III) Porphyrin Catalyzed Aza-Diels–Alder Reaction
Ryota Wakabayashi
Takuya Kurahashi
Seijiro Matsubara
10.1021/ol3020946.s001
https://acs.figshare.com/articles/journal_contribution/Cobalt_III_Porphyrin_Catalyzed_Aza_Diels_Alder_Reaction/2484802
An efficient protocol for the aza-Diels–Alder reaction of electron-deficient 1,3-dienes with unactivated imines in the presence of a cationic cobalt(III) porphyrin complex was developed. The transformation proceeded smoothly to afford the desired piperidine scaffold within 2 h at ambient temperature. Highly chemoselective cycloaddition of imines with dienes in the presence of a variety of carbonyl compounds was also demonstrated.
2012-09-21 00:00:00
unactivated imines
presence
ambient temperature
cobalt
diene
variety
Catalyzed
cationic
transformation
Porphyrin
2 h
piperidine scaffold
porphyrin
ReactionAn
carbonyl compounds
Cobalt
chemoselective cycloaddition