10.1021/nn302615f.s001
Brittany R. Bitner
Brittany R.
Bitner
Daniela C. Marcano
Daniela C.
Marcano
Jacob M. Berlin
Jacob M.
Berlin
Roderic H. Fabian
Roderic H.
Fabian
Leela Cherian
Leela
Cherian
James C. Culver
James C.
Culver
Mary E. Dickinson
Mary E.
Dickinson
Claudia S. Robertson
Claudia S.
Robertson
Robia G. Pautler
Robia G.
Pautler
Thomas A. Kent
Thomas A.
Kent
James M. Tour
James M.
Tour
Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury
American Chemical Society
2012
nitric oxide levels
Antioxidant Carbon Particles
Middle East theaters
CBF
TBI
brain injury
Cerebrovascular
outcome
Traumatic Brain InjuryInjury
2012-09-25 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Antioxidant_Carbon_Particles_Improve_Cerebrovascular_Dysfunction_Following_Traumatic_Brain_Injury/2483827
Injury to the neurovasculature is a feature of brain injury and must be addressed to maximize opportunity for improvement. Cerebrovascular dysfunction, manifested by reduction in cerebral blood flow (CBF), is a key factor that worsens outcome after traumatic brain injury (TBI), most notably under conditions of hypotension. We report here that a new class of antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), which are nontoxic carbon particles, rapidly restore CBF in a mild TBI/hypotension/resuscitation rat model when administered during resuscitationa clinically relevant time point. Along with restoration of CBF, there is a concomitant normalization of superoxide and nitric oxide levels. Given the role of poor CBF in determining outcome, this finding is of major importance for improving patient health under clinically relevant conditions during resuscitative care, and it has direct implications for the current TBI/hypotension war-fighter victims in the Afghanistan and Middle East theaters. The results also have relevancy in other related acute circumstances such as stroke and organ transplantation.