10.1021/ol3025956.s001
Andrew D. Wadsworth
Andrew D.
Wadsworth
Daniel P. Furkert
Daniel P.
Furkert
Jonathan Sperry
Jonathan
Sperry
Margaret A. Brimble
Margaret A.
Brimble
Total Synthesis of the Initially Reported and Revised Structures of the Neuroprotective Agent Palmyrolide A
American Chemical Society
2012
Total Synthesis
metathesi
Revised Structures
revision
Reported
sequential ring
synthese
Neuroprotective Agent Palmyrolide AThe
neuroprotective agent palmyrolide
isomerization
macrocyclization step
2012-10-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Initially_Reported_and_Revised_Structures_of_the_Neuroprotective_Agent_Palmyrolide_A/2476888
The total syntheses of the initially reported and revised structures of the neuroprotective agent palmyrolide A are reported. The key macrocyclization step was achieved using a sequential ring closing metathesis/olefin isomerization reaction. The synthetic work described herein serves to confirm the recent structural revision of this unusual natural product.