10.1021/ol3025956.s001 Andrew D. Wadsworth Andrew D. Wadsworth Daniel P. Furkert Daniel P. Furkert Jonathan Sperry Jonathan Sperry Margaret A. Brimble Margaret A. Brimble Total Synthesis of the Initially Reported and Revised Structures of the Neuroprotective Agent Palmyrolide A American Chemical Society 2012 Total Synthesis metathesi Revised Structures revision Reported sequential ring synthese Neuroprotective Agent Palmyrolide AThe neuroprotective agent palmyrolide isomerization macrocyclization step 2012-10-19 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_the_Initially_Reported_and_Revised_Structures_of_the_Neuroprotective_Agent_Palmyrolide_A/2476888 The total syntheses of the initially reported and revised structures of the neuroprotective agent palmyrolide A are reported. The key macrocyclization step was achieved using a sequential ring closing metathesis/olefin isomerization reaction. The synthetic work described herein serves to confirm the recent structural revision of this unusual natural product.