%0 Journal Article %A Shibata, Norio %A Fukushi, Kazunobu %A Furukawa, Tatsuya %A Suzuki, Satoru %A Tokunaga, Etsuko %A Cahard, Dominique %D 2012 %T Decarboxylative Allylation of Trifluoroethyl Sulfones and Approach to Difluoromethyl Compounds %U https://acs.figshare.com/articles/journal_contribution/Decarboxylative_Allylation_of_Trifluoroethyl_Sulfones_and_Approach_to_Difluoromethyl_Compounds/2476882 %R 10.1021/ol302589w.s001 %2 https://acs.figshare.com/ndownloader/files/4119586 %K generation %K trifluoroethyl carbanion %K ethyl allyl carbonates act %K Approach %K conditions thanks %K trifluoroethyl phenyl sulfones %K Decarboxylative Allylation %K Difluoromethyl CompoundsAllyl carbonates %K decarboxylative %K utility %K approach %K method %K Trifluoroethyl Sulfones %K difluoromethyl compounds %K allylation %K ethoxide %K allylpalladium %K source %X Allyl carbonates undergo palladium-catalyzed decarboxylative allylation of trifluoroethyl phenyl sulfones. The success of the allylation, which is not efficient under typical strong base-mediated conditions, is the result of mild conditions thanks to a progressive delivery of ethoxide. Indeed, ethyl allyl carbonates act as a latent source of ethoxide for generation of the trifluoroethyl carbanion that reacts with the π-allylpalladium complex. The utility of the method is illustrated in a new approach to difluoromethyl compounds. %I ACS Publications