10.1021/ol302593z.s001
Tsuyoshi Ueda
Tsuyoshi
Ueda
Hideyuki Konishi
Hideyuki
Konishi
Kei Manabe
Kei
Manabe
Trichlorophenyl Formate: Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed Carbonylation of Aryl/Alkenyl Halides and Triflates
American Chemical Society
2012
carboxylic acid derivatives
Trichlorophenyl Formate
NEt 3
rt
carbonylation
trichlorophenyl esters
formate
Accessible Crystalline CO Surrogate
2012-10-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Trichlorophenyl_Formate_Highly_Reactive_and_Easily_Accessible_Crystalline_CO_Surrogate_for_Palladium_Catalyzed_Carbonylation_of_Aryl_Alkenyl_Halides_and_Triflates/2476873
The high utility of 2,4,6-trichlorophenyl formate, a highly reactive and easily accessible crystalline CO surrogate, is demonstrated. The decarbonylation with NEt<sub>3</sub> to generate CO proceeded rapidly at rt, thereby allowing external-CO-free Pd-catalyzed carbonylation of aryl/alkenyl halides and triflates. The high reactivity of the CO surrogate enabled carbonylation at rt and significantly reduced the quantities of formate to near-stoichiometric levels. The obtained trichlorophenyl esters can be readily converted to a variety of carboxylic acid derivatives in high yields.