10.1021/ol302527z.s005 Bor-Cherng Hong Bor-Cherng Hong Nitin S. Dange Nitin S. Dange Po-Jen Yen Po-Jen Yen Gene-Hsiang Lee Gene-Hsiang Lee Ju-Hsiou Liao Ju-Hsiou Liao Organocatalytic Asymmetric <i>Anti</i>-Selective Michael Reactions of Aldehydes and the Sequential Reduction/Lactonization/Pauson–Khand Reaction for the Enantioselective Synthesis of Highly Functionalized Hydropentalenes American Chemical Society 2016 Organocatalytic ee Sequential Aldehyde organocatalytic configuration Asymmetric sequence enantioselective synthesis method stereoselectivity Functionalized HydropentalenesA functionalized hydropentalenes stereogenic centers analysis Enantioselective Synthesis 2016-02-20 08:36:08 Dataset https://acs.figshare.com/articles/dataset/Organocatalytic_Asymmetric_i_Anti_i_Selective_Michael_Reactions_of_Aldehydes_and_the_Sequential_Reduction_Lactonization_Pauson_Khand_Reaction_for_the_Enantioselective_Synthesis_of_Highly_Functionalized_Hydropentalenes/2476870 A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% <i>ee</i>). This process combines an enantioselective organocatalytic <i>anti</i>-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson–Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.