10.1021/ol302527z.s005
Bor-Cherng Hong
Bor-Cherng
Hong
Nitin S. Dange
Nitin S.
Dange
Po-Jen Yen
Po-Jen
Yen
Gene-Hsiang Lee
Gene-Hsiang
Lee
Ju-Hsiou Liao
Ju-Hsiou
Liao
Organocatalytic Asymmetric <i>Anti</i>-Selective Michael Reactions of Aldehydes and the Sequential Reduction/Lactonization/Pauson–Khand Reaction for the Enantioselective Synthesis of Highly Functionalized Hydropentalenes
American Chemical Society
2016
Organocatalytic
ee
Sequential
Aldehyde
organocatalytic
configuration
Asymmetric
sequence
enantioselective synthesis
method
stereoselectivity
Functionalized HydropentalenesA
functionalized hydropentalenes
stereogenic centers
analysis
Enantioselective Synthesis
2016-02-20 08:36:08
Dataset
https://acs.figshare.com/articles/dataset/Organocatalytic_Asymmetric_i_Anti_i_Selective_Michael_Reactions_of_Aldehydes_and_the_Sequential_Reduction_Lactonization_Pauson_Khand_Reaction_for_the_Enantioselective_Synthesis_of_Highly_Functionalized_Hydropentalenes/2476870
A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% <i>ee</i>). This process combines an enantioselective organocatalytic <i>anti</i>-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson–Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.