Organocatalytic Asymmetric <i>Anti</i>-Selective Michael Reactions of Aldehydes and the Sequential Reduction/Lactonization/Pauson–Khand Reaction for the Enantioselective Synthesis of Highly Functionalized Hydropentalenes Bor-Cherng Hong Nitin S. Dange Po-Jen Yen Gene-Hsiang Lee Ju-Hsiou Liao 10.1021/ol302527z.s002 https://acs.figshare.com/articles/dataset/Organocatalytic_Asymmetric_i_Anti_i_Selective_Michael_Reactions_of_Aldehydes_and_the_Sequential_Reduction_Lactonization_Pauson_Khand_Reaction_for_the_Enantioselective_Synthesis_of_Highly_Functionalized_Hydropentalenes/2476858 A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% <i>ee</i>). This process combines an enantioselective organocatalytic <i>anti</i>-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson–Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis. 2016-02-20 08:35:54 Organocatalytic ee Sequential Aldehyde organocatalytic configuration Asymmetric sequence enantioselective synthesis method stereoselectivity Functionalized HydropentalenesA functionalized hydropentalenes stereogenic centers analysis Enantioselective Synthesis