10.1021/ol302535r.s001
Raul A. Leal
Raul A.
Leal
Danial R. Beaudry
Danial R.
Beaudry
Saeed K. Alzghari
Saeed K.
Alzghari
Richmond Sarpong
Richmond
Sarpong
Synthesis of the Pentacyclic Skeleton of the Indole Alkaloid Arboflorine
American Chemical Society
2012
dehydrogenative
convergent
Indole Alkaloid ArboflorineAn
Suzuki
Pentacyclic Skeleton
indole
functionalization
pentacyclic core
synthesis
transannular
borylative
Kopsia alkaloid arboflorine
Synthesi
bond
2012-10-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_the_Pentacyclic_Skeleton_of_the_Indole_Alkaloid_Arboflorine/2476852
An effective synthesis of the pentacyclic core of the unusual <i>Kopsia</i> alkaloid arboflorine is reported. The success of the synthetic route rested on the use of a borylative C–H functionalization reaction, a convergent Suzuki cross-coupling to a C(2) halogenated indole, and an unprecedented transannular dehydrogenative C–N bond forming reaction.