10.1021/ol302680m.s002
Jonathan K. Lam
Jonathan K.
Lam
Yvonne Schmidt
Yvonne
Schmidt
Christopher D. Vanderwal
Christopher D.
Vanderwal
Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts
American Chemical Society
2012
Alkene metathesis processes
lactam
CycloadductsThe
Complex Polycyclic Scaffolds
cycloaddition
utility
Metathesis Rearrangement
access
product synthesis
Arene
30 years
cycloadduct
Henn
arene
Himbert
intramolecular
polycyclic compounds
2012-11-02 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Complex_Polycyclic_Scaffolds_by_Metathesis_Rearrangement_of_Himbert_Arene_Allene_Cycloadducts/2473381
The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.