10.1021/ol302680m.s002 Jonathan K. Lam Jonathan K. Lam Yvonne Schmidt Yvonne Schmidt Christopher D. Vanderwal Christopher D. Vanderwal Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts American Chemical Society 2012 Alkene metathesis processes lactam CycloadductsThe Complex Polycyclic Scaffolds cycloaddition utility Metathesis Rearrangement access product synthesis Arene 30 years cycloadduct Henn arene Himbert intramolecular polycyclic compounds 2012-11-02 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Complex_Polycyclic_Scaffolds_by_Metathesis_Rearrangement_of_Himbert_Arene_Allene_Cycloadducts/2473381 The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.