Commercial Zinc Oxide:
A Facile, Efficient, and Eco-friendly
Catalyst for the One-Pot Three-Component Synthesis of Multisubstituted
2‑Aminothiophenes via the Gewald Reaction
Reza Tayebee
S. Javad Ahmadi
Esmaeil Rezaei Seresht
Farzad Javadi
Mohammad A. Yasemi
Morteza Hosseinpour
Behrouz Maleki
10.1021/ie301737h.s001
https://acs.figshare.com/articles/journal_contribution/Commercial_Zinc_Oxide_A_Facile_Efficient_and_Eco_friendly_Catalyst_for_the_One_Pot_Three_Component_Synthesis_of_Multisubstituted_2_Aminothiophenes_via_the_Gewald_Reaction/2471239
An eco-friendly, simple, and effective protocol is developed
for
the synthesis of various multisubstituted 2-aminothiophenes. In the
presence of a catalytic amount of ZnO (5 mol %), ketones or
aldehydes, malononitrile and elemental sulfur were converted to the
corresponding 2-aminothiophene derivatives in moderate to high yields
(27%–70%) under solvent-free conditions at 100 °C. Zinc
oxide as an efficient, readily available, and reusable catalyst, showed
very good catalytic activity for the synthesis of 2-aminothiophene
derivatives. Thus far, little research has been reported on the Gewald
reaction under solvent-free conditions; to the best of our knowledge,
this is the first time that it has been proposed as an inexpensive
and readily available catalyst for use in the target synthetic route.
2016-02-20 06:55:34
synthesis
derivative
aminothiophene
Zinc oxide
catalyst
Commercial Zinc Oxide
Gewald reaction