Commercial Zinc Oxide: A Facile, Efficient, and Eco-friendly Catalyst for the One-Pot Three-Component Synthesis of Multisubstituted 2‑Aminothiophenes via the Gewald Reaction Reza Tayebee S. Javad Ahmadi Esmaeil Rezaei Seresht Farzad Javadi Mohammad A. Yasemi Morteza Hosseinpour Behrouz Maleki 10.1021/ie301737h.s001 https://acs.figshare.com/articles/journal_contribution/Commercial_Zinc_Oxide_A_Facile_Efficient_and_Eco_friendly_Catalyst_for_the_One_Pot_Three_Component_Synthesis_of_Multisubstituted_2_Aminothiophenes_via_the_Gewald_Reaction/2471239 An eco-friendly, simple, and effective protocol is developed for the synthesis of various multisubstituted 2-aminothiophenes. In the presence of a catalytic amount of ZnO (5 mol %), ketones or aldehydes, malononitrile and elemental sulfur were converted to the corresponding 2-aminothiophene derivatives in moderate to high yields (27%–70%) under solvent-free conditions at 100 °C. Zinc oxide as an efficient, readily available, and reusable catalyst, showed very good catalytic activity for the synthesis of 2-aminothiophene derivatives. Thus far, little research has been reported on the Gewald reaction under solvent-free conditions; to the best of our knowledge, this is the first time that it has been proposed as an inexpensive and readily available catalyst for use in the target synthetic route. 2016-02-20 06:55:34 synthesis derivative aminothiophene Zinc oxide catalyst Commercial Zinc Oxide Gewald reaction