10.1021/mp300382n.s001
Santiago Rojas
Santiago
Rojas
Juan Domingo Gispert
Juan Domingo
Gispert
Sergio Abad
Sergio
Abad
Mireia Buaki-Sogo
Mireia
Buaki-Sogo
Victor
M. Victor
Victor
M.
Victor
Hermenegildo Garcia
Hermenegildo
Garcia
Jose Raúl Herance
Jose Raúl
Herance
In Vivo Biodistribution of Amino-Functionalized Ceria
Nanoparticles in Rats Using Positron Emission Tomography
American Chemical Society
2016
Radiolabeled ceria nanoparticles
positron emission tomography
18 F isotope
vivo biodistribution
Positron Emission TomographyA variety
radiolabeled nanoparticulate material
2016-02-20 04:58:14
Journal contribution
https://acs.figshare.com/articles/journal_contribution/In_Vivo_Biodistribution_of_Amino_Functionalized_Ceria_Nanoparticles_in_Rats_Using_Positron_Emission_Tomography/2464720
A variety of nanoparticles have been
proposed for several biomedical
applications. To gauge the therapeutic potential of these nanoparticles,
in vivo biodistribution is essential and mandatory. In the present
study, ceria nanoparticles (5 nm average particle size) were labeled
with <sup>18</sup>F to study their in vivo biodistribution in rats
by positron emission tomography (PET). The <sup>18</sup>F isotope
was anchored by reaction of <i>N</i>-succinimidyl 4-[<sup>18</sup>F]fluorobenzoate (<sup>18</sup>F-SFB) with a modified nanoparticle
surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled
ceria nanoparticles accumulated mainly in lungs, spleen, and liver.
Metabolic products of the radiolabeled nanoparticulate material were
excreted into the urinary tract.