10.1021/mp300382n.s001 Santiago Rojas Santiago Rojas Juan Domingo Gispert Juan Domingo Gispert Sergio Abad Sergio Abad Mireia Buaki-Sogo Mireia Buaki-Sogo Victor M. Victor Victor M. Victor Hermenegildo Garcia Hermenegildo Garcia Jose Raúl Herance Jose Raúl Herance In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography American Chemical Society 2016 Radiolabeled ceria nanoparticles positron emission tomography 18 F isotope vivo biodistribution Positron Emission TomographyA variety radiolabeled nanoparticulate material 2016-02-20 04:58:14 Journal contribution https://acs.figshare.com/articles/journal_contribution/In_Vivo_Biodistribution_of_Amino_Functionalized_Ceria_Nanoparticles_in_Rats_Using_Positron_Emission_Tomography/2464720 A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with <sup>18</sup>F to study their in vivo biodistribution in rats by positron emission tomography (PET). The <sup>18</sup>F isotope was anchored by reaction of <i>N</i>-succinimidyl 4-[<sup>18</sup>F]­fluorobenzoate (<sup>18</sup>F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.