10.1021/ja308523f.s002 Priyalakshmi Viswanathan Priyalakshmi Viswanathan Somyot Chirasatitsin Somyot Chirasatitsin Kamolchanok Ngamkham Kamolchanok Ngamkham Adam J. Engler Adam J. Engler Giuseppe Battaglia Giuseppe Battaglia Cell Instructive Microporous Scaffolds through Interface Engineering American Chemical Society 2012 templating characterization surface topology manner regenerative medicine protein phase emulsion hMSC extracellular matrix ECM nanoscopic domains chemical properties phase separation foam pores synthesis surfactant HIPE process novel biomaterials Interface EngineeringThe design cell Instructive Microporous Scaffolds amphiphilic copolymers incorporation interface 2012-12-12 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Cell_Instructive_Microporous_Scaffolds_through_Interface_Engineering/2460595 The design of novel biomaterials for regenerative medicine requires incorporation of well-defined physical and chemical properties that mimic the native extracellular matrix (ECM). Here, we report the synthesis and characterization of porous foams prepared by high internal phase emulsion (HIPE) templating using amphiphilic copolymers that act as surfactants during the HIPE process. We combine different copolymers exploiting oil–water interface confined phase separation to engineer the surface topology of foam pores with nanoscopic domains of cell inert and active chemistries mimicking native matrix. We further demonstrate how proteins and hMSCs adhere in a domain specific manner.