10.1021/ja308523f.s002
Priyalakshmi Viswanathan
Priyalakshmi
Viswanathan
Somyot Chirasatitsin
Somyot
Chirasatitsin
Kamolchanok Ngamkham
Kamolchanok
Ngamkham
Adam J. Engler
Adam J.
Engler
Giuseppe Battaglia
Giuseppe
Battaglia
Cell Instructive Microporous
Scaffolds through Interface
Engineering
American Chemical Society
2012
templating
characterization
surface topology
manner
regenerative medicine
protein
phase emulsion
hMSC
extracellular matrix
ECM
nanoscopic domains
chemical properties
phase separation
foam pores
synthesis
surfactant
HIPE process
novel biomaterials
Interface EngineeringThe design
cell Instructive Microporous Scaffolds
amphiphilic copolymers
incorporation
interface
2012-12-12 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Cell_Instructive_Microporous_Scaffolds_through_Interface_Engineering/2460595
The design of novel biomaterials for regenerative medicine
requires
incorporation of well-defined physical and chemical properties that
mimic the native extracellular matrix (ECM). Here, we report the synthesis
and characterization of porous foams prepared by high internal phase
emulsion (HIPE) templating using amphiphilic copolymers that act as
surfactants during the HIPE process. We combine different copolymers
exploiting oil–water interface confined phase separation to
engineer the surface topology of foam pores with nanoscopic domains
of cell inert and active chemistries mimicking native matrix. We further
demonstrate how proteins and hMSCs adhere in a domain specific manner.