Schmitt, Daniel C. Dechert-Schmitt, Anne-Marie R. Krische, Michael J. Iridium-Catalyzed Allylation of Chiral β‑Stereogenic Alcohols: Bypassing Discrete Formation of Epimerizable Aldehydes The cyclometalated π-allyliridium 3,4-dinitro-<i>C,O</i>-benzoate complex modified by (<i>R</i>)- or (<i>S</i>)-Cl,MeO-BIPHEP promotes the transfer hydrogenative coupling of allyl acetate to β-stereogenic alcohols with good to excellent levels of catalyst-directed diastereoselectivity to furnish homoallylic alcohols. Remote electronic effects of the <i>C,O</i>-benzoate of the catalyst play a critical role in suppressing epimerization of the transient α-stereogenic aldehyde. AldehydesThe;transfer hydrogenative;stereogenic;diastereoselectivity;Epimerizable;allyliridium;aldehyde;Allylation;Bypassing Discrete Formation;cyclometalated;allyl acetate;Chiral;catalyst;Remote;epimerization;homoallylic alcohols;Stereogenic;role 2012-12-21
    https://acs.figshare.com/articles/journal_contribution/Iridium_Catalyzed_Allylation_of_Chiral_Stereogenic_Alcohols_Bypassing_Discrete_Formation_of_Epimerizable_Aldehydes/2458717
10.1021/ol3030692.s001