10.1021/ol303154k.s001
Feng Shi
Feng
Shi
Gui-Juan Xing
Gui-Juan
Xing
Ren-Yi Zhu
Ren-Yi
Zhu
Wei Tan
Wei
Tan
Shujiang Tu
Shujiang
Tu
A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold
American Chemical Society
2013
Catalytic
Spiro
Diastereo
ee
creation
yield
quaternary stereogenic centers
enantioenriched
spiro
Asymmetric
scaffold
access
stereoselectivitie
ScaffoldThe
Enantioselective Construction
approach
method
dr
Povarov
2013-01-04 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/A_Catalytic_Asymmetric_Isatin_Involved_Povarov_Reaction_Diastereo_and_Enantioselective_Construction_of_Spiro_indolin_3_2_quinoline_Scaffold/2455528
The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 <i>dr</i>'s, up to 97% <i>ee</i>).