10.1021/ol303154k.s001 Feng Shi Feng Shi Gui-Juan Xing Gui-Juan Xing Ren-Yi Zhu Ren-Yi Zhu Wei Tan Wei Tan Shujiang Tu Shujiang Tu A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold American Chemical Society 2013 Catalytic Spiro Diastereo ee creation yield quaternary stereogenic centers enantioenriched spiro Asymmetric scaffold access stereoselectivitie ScaffoldThe Enantioselective Construction approach method dr Povarov 2013-01-04 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/A_Catalytic_Asymmetric_Isatin_Involved_Povarov_Reaction_Diastereo_and_Enantioselective_Construction_of_Spiro_indolin_3_2_quinoline_Scaffold/2455528 The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 <i>dr</i>'s, up to 97% <i>ee</i>).