Huh, Jun R. Englund, Erika E. Wang, Hang Huang, Ruili Huang, Pengxiang Rastinejad, Fraydoon Inglese, James Austin, Christopher P. Johnson, Ronald L. Huang, Wenwei Littman, Dan R. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of T<sub>H</sub>17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat T<sub>H</sub>17-related autoimmune diseases. Herein, we describe the identification of a series of diphenylpropanamides as novel and selective RORγ antagonists. Diphenylpropanamide <b>4n</b> inhibited the transcriptional activity of RORγt, but not RORα, in cells. In addition, it suppressed human T<sub>H</sub>17 cell differentiation at submicromolar concentrations. transcriptional activity;Antagonizing ROR γt transcriptional activity;receptor ROR γt;submicromolar concentrations;TH 17 cells;ROR γ antagonists;ROR γt;Diphenylpropanamide 4 n;TH 17 cell differentiation 2013-01-10
    https://acs.figshare.com/articles/journal_contribution/Identification_of_Potent_and_Selective_Diphenylpropanamide_ROR_Inhibitors/2453470
10.1021/ml300286h.s001