Hazra, Abhijit Bharitkar, Yogesh P. Chakraborty, Debanjana Mondal, Susanta Kumar Singal, Nupur Mondal, Shyamal Maity, Arindam Paira, Rupankar Banerjee, Sukdeb Mondal, Nirup B. Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3-Dipolar Cycloaddition Reaction Under Microwave Irradiation Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/<i>N</i>-benzyl glycine to l-proline changes the regiochemistry. A representative library of 40 compounds along with in vitro anticancer evaluation is reported. irradiation;glycine;anticancer evaluation;Andrographolide;Dipolar;acid;regioselective;MW;Stereoselective Synthesis;Regio;representative library;nature;Bioactive;oxindole;40 compounds;sarcosine;stereo;andrographolide;regiochemistry;chemo;azomethine ylide cycloaddition;Cycloaddition 2013-01-14
    https://acs.figshare.com/articles/journal_contribution/Regio_and_Stereoselective_Synthesis_of_a_Library_of_Bioactive_Dispiro_Oxindolo_Acenaphthoquino_Andrographolides_via_1_3_Dipolar_Cycloaddition_Reaction_Under_Microwave_Irradiation/2452690
10.1021/co3001154.s001