10.1021/ol303440y.s001 Tao-Shan Jiang Tao-Shan Jiang Guan-Wu Wang Guan-Wu Wang Synthesis of 3‑Acylindoles by Palladium-Catalyzed Acylation of Free (N–H) Indoles with Nitriles American Chemical Society 2013 Indole Acylation mechanism Pd indole acid additive ketimine Free synthesis Acylindole nitrile NitrilesAn acylation reaction hydrolysis carbopalladation acylindole Synthesi 2013-02-15 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Synthesis_of_3_Acylindoles_by_Palladium_Catalyzed_Acylation_of_Free_N_H_Indoles_with_Nitriles/2442943 An efficient palladium-catalyzed synthesis of 3-acylindoles using free (N–H) indoles and nitriles has been developed. The acylation reaction proceeded well under the Pd(OAc)<sub>2</sub>/2,2′-bipyridine system and with d-(+)-camphorsulfonic acid as the additive. A possible mechanism involving carbopalladation of nitriles and subsequent hydrolysis of ketimines is proposed.