10.1021/ol303440y.s001
Tao-Shan Jiang
Tao-Shan
Jiang
Guan-Wu Wang
Guan-Wu
Wang
Synthesis of 3‑Acylindoles by Palladium-Catalyzed Acylation of Free (N–H) Indoles with Nitriles
American Chemical Society
2013
Indole
Acylation
mechanism
Pd
indole
acid
additive
ketimine
Free
synthesis
Acylindole
nitrile
NitrilesAn
acylation reaction
hydrolysis
carbopalladation
acylindole
Synthesi
2013-02-15 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_3_Acylindoles_by_Palladium_Catalyzed_Acylation_of_Free_N_H_Indoles_with_Nitriles/2442943
An efficient palladium-catalyzed synthesis of 3-acylindoles using free (N–H) indoles and nitriles has been developed. The acylation reaction proceeded well under the Pd(OAc)<sub>2</sub>/2,2′-bipyridine system and with d-(+)-camphorsulfonic acid as the additive. A possible mechanism involving carbopalladation of nitriles and subsequent hydrolysis of ketimines is proposed.