Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi Yit-Heng Chooi Jinxu Fang Hong Liu Scott G. Filler Pin Wang Yi Tang 10.1021/ol303435y.s001 https://acs.figshare.com/articles/journal_contribution/Genome_Mining_of_a_Prenylated_and_Immunosuppressive_Polyketide_from_Pathogenic_Fungi/2442940 Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in <i>Aspergillus fumigatus</i> and <i>Neosartorya fischeri</i> led to isolation of a new metabolite neosartoricin (<b>3</b>). The structure of <b>3</b> was solved by X-ray crystallography and NMR to be a prenylated anthracenone. <b>3</b> exhibits T-cell antiproliferative activity with an IC<sub>50</sub> of 3 μM, suggestive of a physiological role as an immunosuppressive agent. 2013-02-15 00:00:00 exhibit agent antiproliferative cluster crystallography genome Mining Aspergillus fumigatus Prenylated pcPTase neosartoricin role IC 50 prenylated anthracenone NMR Immunosuppressive Polyketide Pathogenic FungiActivation metabolite Neosartorya fischeri 3 μ M polycyclic polyketide prenyltransferase isolation