Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
Yit-Heng Chooi
Jinxu Fang
Hong Liu
Scott G. Filler
Pin Wang
Yi Tang
10.1021/ol303435y.s001
https://acs.figshare.com/articles/journal_contribution/Genome_Mining_of_a_Prenylated_and_Immunosuppressive_Polyketide_from_Pathogenic_Fungi/2442940
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in <i>Aspergillus fumigatus</i> and <i>Neosartorya fischeri</i> led to isolation of a new metabolite neosartoricin (<b>3</b>). The structure of <b>3</b> was solved by X-ray crystallography and NMR to be a prenylated anthracenone. <b>3</b> exhibits T-cell antiproliferative activity with an IC<sub>50</sub> of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
2013-02-15 00:00:00
exhibit
agent
antiproliferative
cluster
crystallography
genome Mining
Aspergillus fumigatus
Prenylated
pcPTase
neosartoricin
role
IC 50
prenylated anthracenone
NMR
Immunosuppressive Polyketide
Pathogenic FungiActivation
metabolite
Neosartorya fischeri
3 μ M
polycyclic polyketide prenyltransferase
isolation