10.1021/ol303381c.s002 Kohei Orimoto Kohei Orimoto Harufumi Oyama Harufumi Oyama Yuki Namera Yuki Namera Takashi Niwa Takashi Niwa Masahisa Nakada Masahisa Nakada Catalytic Asymmetric [4 + 2] Cycloadditions and Hosomi–Sakurai Reactions of α‑Alkylidene β‑Keto Imides American Chemical Society 2013 alkylidene Hosomi ring junction cycloaddition enantioselective imide keto Alkylidene 2013-02-15 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Catalytic_Asymmetric_4_2_Cycloadditions_and_Hosomi_Sakurai_Reactions_of_Alkylidene_Keto_Imides/2442931 Highly enantioselective catalytic asymmetric reactions of rationally designed α-alkylidene β-keto imides are described. The [4 + 2] cycloadditions and Hosomi–Sakurai reactions of α-alkylidene β-keto imides proceed with high enantioselectivity and yield. The [4 + 2] cycloadditions of the imides with various dienes afford products bearing an all-carbon quaternary stereogenic center at the ring junction. α-Alkylidene β-keto imides should be useful for the enantioselective total synthesis of natural products and other catalytic asymmetric applications.