Simple and Efficient Catalytic Reaction for the Selective
Deuteration of Alcohols
Eugene Khaskin
David Milstein
10.1021/cs400092p.s001
https://acs.figshare.com/articles/journal_contribution/Simple_and_Efficient_Catalytic_Reaction_for_the_Selective_Deuteration_of_Alcohols/2438287
A highly
efficient system for the catalytic deuteration of α
and β CH bonds of primary and secondary alcohols has been developed.
The deuterium source is D<sub>2</sub>O. Together with the low catalyst
loadings and the simple experimental setup, the reaction has direct
application to the synthesis of bioactive isotopologues and the direct
synthesis of fully deuterated substrates, such as ethanol-<i>d</i><sub>6</sub>. The current system represents a significant
advance in practicality for homogeneous metal catalyzed systems that
carry out H/D exchange in organic substrates with water.
2013-03-01 00:00:00
Efficient Catalytic Reaction
bioactive isotopologues
D 2O
deuterium source
synthesis
Selective Deuteration
substrate
catalyst loadings
β CH bonds