10.1021/nn400359c.s001 Nicholas J. Kybert Nicholas J. Kybert Mitchell B. Lerner Mitchell B. Lerner Jeremy S. Yodh Jeremy S. Yodh George Preti George Preti A. T. Charlie Johnson A. T. Charlie Johnson Differentiation of Complex Vapor Mixtures Using Versatile DNA–Carbon Nanotube Chemical Sensor Arrays American Chemical Society 2016 vapor sensors target analytes fabrication methods Complex Vapor Mixtures Critical challenges DNA chemical detection NT field effect transistors functionalized functionalized carbon nanotubes chemical diversity equilibrium thermodynamics functionalization schemes scalable approach 2016-02-19 16:10:44 Journal contribution https://acs.figshare.com/articles/journal_contribution/Differentiation_of_Complex_Vapor_Mixtures_Using_Versatile_DNA_Carbon_Nanotube_Chemical_Sensor_Arrays/2431492 Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of NT-based sensor arrays for chemical detection include the demonstration of reproducible fabrication methods and functionalization schemes that provide high chemical diversity to the resulting sensors. Here, we outline a scalable approach to fabricating arrays of vapor sensors consisting of NT field effect transistors functionalized with single-stranded DNA (DNA-NT). DNA-NT sensors were highly reproducible, with responses that could be described through equilibrium thermodynamics. Target analytes were detected even in large backgrounds of volatile interferents. DNA-NT sensors were able to discriminate between highly similar molecules, including structural isomers and enantiomers. The sensors were also able to detect subtle variations in complex vapors, including mixtures of structural isomers and mixtures of many volatile organic compounds characteristic of humans.