10.1021/nn400359c.s001
Nicholas J. Kybert
Nicholas J.
Kybert
Mitchell B. Lerner
Mitchell B.
Lerner
Jeremy S. Yodh
Jeremy S.
Yodh
George Preti
George
Preti
A. T. Charlie Johnson
A.
T. Charlie Johnson
Differentiation of Complex Vapor Mixtures Using Versatile DNA–Carbon Nanotube Chemical Sensor Arrays
American Chemical Society
2016
vapor sensors
target analytes
fabrication methods
Complex Vapor Mixtures
Critical challenges
DNA
chemical detection
NT field effect transistors functionalized
functionalized carbon nanotubes
chemical diversity
equilibrium thermodynamics
functionalization schemes
scalable approach
2016-02-19 16:10:44
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Differentiation_of_Complex_Vapor_Mixtures_Using_Versatile_DNA_Carbon_Nanotube_Chemical_Sensor_Arrays/2431492
Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of NT-based sensor arrays for chemical detection include the demonstration of reproducible fabrication methods and functionalization schemes that provide high chemical diversity to the resulting sensors. Here, we outline a scalable approach to fabricating arrays of vapor sensors consisting of NT field effect transistors functionalized with single-stranded DNA (DNA-NT). DNA-NT sensors were highly reproducible, with responses that could be described through equilibrium thermodynamics. Target analytes were detected even in large backgrounds of volatile interferents. DNA-NT sensors were able to discriminate between highly similar molecules, including structural isomers and enantiomers. The sensors were also able to detect subtle variations in complex vapors, including mixtures of structural isomers and mixtures of many volatile organic compounds characteristic of humans.