Asymmetric Methallylation of Ketones Catalyzed by a Highly Active Organocatalyst 3,3′‑F<sub>2</sub>‑BINOL
Yongda Zhang
Ning Li
Bo Qu
Shengli Ma
Heewon Lee
Nina C. Gonnella
Joe Gao
Wenjie Li
Zhulin Tan
Jonathan T. Reeves
Jun Wang
Jon C. Lorenz
Guisheng Li
Diana C. Reeves
Ajith Premasiri
Nelu Grinberg
Nizar Haddad
Bruce Z. Lu
Jinhua J. Song
Chris H. Senanayake
10.1021/ol400498a.s001
https://acs.figshare.com/articles/journal_contribution/Asymmetric_Methallylation_of_Ketones_Catalyzed_by_a_Highly_Active_Organocatalyst_3_3_F_sub_2_sub_BINOL/2427478
(<i>S</i>)-3,3′-F<sub>2</sub>-BINOL has been synthesized for the first time and demonstrated as a highly active organocatalyst for asymmetric methallylation of ketones. Up to 98:2 enantioselectivity and 99% yield were obtained with 5 mol % catalyst loading. The catalyst (<i>S</i>)-3,3′-F<sub>2</sub>-BINOL could be easily recovered and reused.
2013-04-05 00:00:00
Asymmetric Methallylation
enantioselectivity
loading
Ketones Catalyzed
methallylation
Organocatalyst
mol
ketone
organocatalyst
catalyst