10.1021/np300792t.s001 Humberto E. Ortega Humberto E. Ortega Paul R. Graupner Paul R. Graupner Yumi Asai Yumi Asai Karen TenDyke Karen TenDyke Dayong Qiu Dayong Qiu Young Yongchun Shen Young Yongchun Shen Nivia Rios Nivia Rios A. Elizabeth Arnold A. Elizabeth Arnold Phyllis D. Coley Phyllis D. Coley Thomas A. Kursar Thomas A. Kursar William H. Gerwick William H. Gerwick Luis Cubilla-Rios Luis Cubilla-Rios Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus <i>Mycoleptodiscus</i> sp. F0194 American Chemical Society 2013 cancer cell lines skeleton Panama Desmotes incomparabilis culture alkaloids 0194Two Cytotoxic Alkaloids Mycoleptodiscin 1 D IC 50 values 2 D NMR spectroscopy combination Endophytic Fungus Mycoleptodiscus sp mycoleptodiscin compound Elucidation endophytic fungus Mycoleptodiscus sp MS data IR spectroscopic nature 2013-04-26 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Mycoleptodiscins_A_and_B_Cytotoxic_Alkaloids_from_the_Endophytic_Fungus_i_Mycoleptodiscus_i_sp_F0194/2420494 Two novel reddish-orange alkaloids, mycoleptodiscin A (<b>1</b>) and mycoleptodiscin B (<b>2</b>), were isolated from liquid cultures of the endophytic fungus <i>Mycoleptodiscus</i> sp. that had been isolated from <i>Desmotes incomparabilis</i> in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (<b>2</b>) was active in inhibiting the growth of cancer cell lines with IC<sub>50</sub> values in the range 0.60–0.78 μM.