10.1021/np300792t.s001
Humberto
E. Ortega
Humberto
E.
Ortega
Paul R. Graupner
Paul R.
Graupner
Yumi Asai
Yumi
Asai
Karen TenDyke
Karen
TenDyke
Dayong Qiu
Dayong
Qiu
Young Yongchun Shen
Young Yongchun
Shen
Nivia Rios
Nivia
Rios
A. Elizabeth Arnold
A. Elizabeth
Arnold
Phyllis D. Coley
Phyllis D.
Coley
Thomas
A. Kursar
Thomas
A.
Kursar
William H. Gerwick
William H.
Gerwick
Luis Cubilla-Rios
Luis
Cubilla-Rios
Mycoleptodiscins
A and B, Cytotoxic Alkaloids from
the Endophytic Fungus <i>Mycoleptodiscus</i> sp. F0194
American Chemical Society
2013
cancer cell lines
skeleton
Panama
Desmotes incomparabilis
culture
alkaloids
0194Two
Cytotoxic Alkaloids
Mycoleptodiscin
1 D
IC 50 values
2 D NMR spectroscopy
combination
Endophytic Fungus Mycoleptodiscus sp
mycoleptodiscin
compound
Elucidation
endophytic fungus Mycoleptodiscus sp
MS data
IR spectroscopic
nature
2013-04-26 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Mycoleptodiscins_A_and_B_Cytotoxic_Alkaloids_from_the_Endophytic_Fungus_i_Mycoleptodiscus_i_sp_F0194/2420494
Two novel reddish-orange alkaloids,
mycoleptodiscin A (<b>1</b>) and mycoleptodiscin B (<b>2</b>), were isolated from liquid
cultures of the endophytic fungus <i>Mycoleptodiscus</i> sp. that had been isolated from <i>Desmotes incomparabilis</i> in Panama. Elucidation of their structures was accomplished using
1D and 2D NMR spectroscopy in combination with IR spectroscopic and
MS data. These compounds are indole-terpenes with a new skeleton uncommon
in nature. Mycoleptodiscin B (<b>2</b>) was active in inhibiting
the growth of cancer cell lines with IC<sub>50</sub> values in the
range 0.60–0.78 μM.