10.1021/co300141j.s006
Afsaneh Zonouzi
Afsaneh
Zonouzi
Fatemeh Hosseinzadeh
Fatemeh
Hosseinzadeh
Nastaran Karimi
Nastaran
Karimi
Roghieh Mirzazadeh
Roghieh
Mirzazadeh
Seik Weng Ng
Seik Weng
Ng
Novel Approaches for the Synthesis of a Library of
Fluorescent Chromenopyrimidine Derivatives
American Chemical Society
2016
compound
domino reaction
Fluorescent Chromenopyrimidine DerivativesA library
Novel Approaches
290 nm
chromenopyrimidine derivatives
fluorescence emission intensity
intramolecular H
2016-02-19 09:14:56
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Novel_Approaches_for_the_Synthesis_of_a_Library_of_Fluorescent_Chromenopyrimidine_Derivatives/2415850
A library of some new fluorescent
chromenopyrimidine derivatives
has been synthesized by new approaches. Water-promoted and one-pot
reaction can produce new dialkylylamino)-5<i>H</i>-chromeno[2,3-<i>d</i>]pyrimidin-2-yl) phenols. These compounds can also be produced
using domino reaction. Two parallel methods are compared. Novel <i>N</i>-alkyl-<i>N</i>-phenyl-5<i>H</i>-chromeno[2,3-<i>d</i>]-pyrimidin-4-amines and 4-alkoxy-5<i>H</i>-chromeno[2,
3-<i>d</i>]pyrimidines are synthesized by Lewis-acid
catalyzed reactions. The fluorescence emission intensity of the four
compounds from each of libraries after excitation in 290 nm is measured.
Compound 2-(4,5-bis(<i>N</i>-methyl-<i>N</i>-phenylamino)-5<i>H</i>-chromeno[2,3-<i>d</i>]pyrimidin-2-yl)phenol was isolated as a byproduct. The
details of an interesting exchangeable intramolecular H- bonding of
two of the new compounds are reported by X-ray analysis data.