10.1021/co300141j.s001 Afsaneh Zonouzi Afsaneh Zonouzi Fatemeh Hosseinzadeh Fatemeh Hosseinzadeh Nastaran Karimi Nastaran Karimi Roghieh Mirzazadeh Roghieh Mirzazadeh Seik Weng Ng Seik Weng Ng Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives American Chemical Society 2016 compound domino reaction Fluorescent Chromenopyrimidine DerivativesA library Novel Approaches 290 nm chromenopyrimidine derivatives fluorescence emission intensity intramolecular H 2016-02-19 09:14:54 Journal contribution https://acs.figshare.com/articles/journal_contribution/Novel_Approaches_for_the_Synthesis_of_a_Library_of_Fluorescent_Chromenopyrimidine_Derivatives/2415847 A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5<i>H</i>-chromeno­[2,3-<i>d</i>]­pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel <i>N</i>-alkyl-<i>N</i>-phenyl-5<i>H</i>-chromeno­[2,3-<i>d</i>]-pyrimidin-4-amines and 4-alkoxy-5<i>H</i>-chromeno­[2, 3-<i>d</i>]­pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis­(<i>N</i>-methyl-<i>N</i>-phenylamino)-5<i>H</i>-chromeno­[2,3-<i>d</i>]­pyrimidin-2-yl)­phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H- bonding of two of the new compounds are reported by X-ray analysis data.