Collective Activation of MRI Agents via Encapsulation
and Disease-Triggered Release
Mathieu
L. Viger
Jagadis Sankaranarayanan
Caroline de Gracia Lux
Minnie Chan
Adah Almutairi
10.1021/ja403167p.s001
https://acs.figshare.com/articles/journal_contribution/Collective_Activation_of_MRI_Agents_via_Encapsulation_and_Disease_Triggered_Release/2410945
An activation mechanism based on
encapsulated ultrasmall gadolinium
oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules
capable of triggered release in response to chemical markers of disease
(i.e., acidic pH, H<sub>2</sub>O<sub>2</sub>) is presented. Inside
the hydrophobic polymeric matrices, the Gd oxide NPs are shielded
from the aqueous environment, silencing their ability to enhance water
proton relaxation. Upon disassembly of the polymeric particles, activation
of multiple contrast agents generates a strong positive contrast enhancement
of >1 order of magnitude.
2013-05-29 00:00:00
contrast enhancement
bioresponsive polymer capsules
H 2O
water proton relaxation
contrast agents
encapsulated ultrasmall gadolinium oxide nanoparticles
Gd oxide NPs
activation
Collective Activation
MRI Agents
chemical markers