10.1021/op400081c.s001
Jason E. Hein
Jason E.
Hein
Blessing Huynh Cao
Blessing Huynh
Cao
Maarten
W. van der Meijden
Maarten
W.
van der Meijden
Michel Leeman
Michel
Leeman
Richard M. Kellogg
Richard M.
Kellogg
Resolution of Omeprazole Using Coupled Preferential
Crystallization: Efficient Separation of a Nonracemizable Conglomerate
Salt under Near-Equilibrium Conditions
American Chemical Society
2016
monopotassium salt diethanol solvate
Omeprazole
Efficient Separation
Nonracemizable Conglomerate Salt
concentration
nucleation
perturbation
crystal growth
ConditionsA
approach
crystallization technique
access
enantiopure conglomerate crystals
isolation
Preferential Crystallization
omeprazole
2016-02-19 05:34:10
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Resolution_of_Omeprazole_Using_Coupled_Preferential_Crystallization_Efficient_Separation_of_a_Nonracemizable_Conglomerate_Salt_under_Near_Equilibrium_Conditions/2403592
A facile
and efficient resolution of omeprazole as the monopotassium
salt diethanol solvate using coupled preferential crystallization
has been developed. This approach uses small perturbations in solution-phase
concentration to control the competing process of selective crystal
growth while suppressing unwanted primary nucleation. The result is
a selective crystallization technique that replaces the traditional
batch-type isolation with a continuous process amenable to scale,
which provides easy access to enantiopure conglomerate crystals.