10.1021/op400081c.s001 Jason E. Hein Jason E. Hein Blessing Huynh Cao Blessing Huynh Cao Maarten W. van der Meijden Maarten W. van der Meijden Michel Leeman Michel Leeman Richard M. Kellogg Richard M. Kellogg Resolution of Omeprazole Using Coupled Preferential Crystallization: Efficient Separation of a Nonracemizable Conglomerate Salt under Near-Equilibrium Conditions American Chemical Society 2016 monopotassium salt diethanol solvate Omeprazole Efficient Separation Nonracemizable Conglomerate Salt concentration nucleation perturbation crystal growth ConditionsA approach crystallization technique access enantiopure conglomerate crystals isolation Preferential Crystallization omeprazole 2016-02-19 05:34:10 Journal contribution https://acs.figshare.com/articles/journal_contribution/Resolution_of_Omeprazole_Using_Coupled_Preferential_Crystallization_Efficient_Separation_of_a_Nonracemizable_Conglomerate_Salt_under_Near_Equilibrium_Conditions/2403592 A facile and efficient resolution of omeprazole as the monopotassium salt diethanol solvate using coupled preferential crystallization has been developed. This approach uses small perturbations in solution-phase concentration to control the competing process of selective crystal growth while suppressing unwanted primary nucleation. The result is a selective crystallization technique that replaces the traditional batch-type isolation with a continuous process amenable to scale, which provides easy access to enantiopure conglomerate crystals.