Yin, Qian Yap, Felix Y. Yin, Lichen Ma, Liang Zhou, Qin Dobrucki, Lawrence W. Fan, Timothy M. Gaba, Ron C. Cheng, Jianjun Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X‑ray Computed Tomography Imaging Biocompatible poly­(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly­(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations. CT images;tumor bed;poly;nanoparticle;time frame;Contrast Agents;contrast agents;diagnosis accuracy;CT contrast 4 h post injection;hexamethylene diisocyanate 2013-09-18
    https://acs.figshare.com/articles/journal_contribution/Poly_iohexol_Nanoparticles_As_Contrast_Agents_for_in_Vivo_X_ray_Computed_Tomography_Imaging/2375845
10.1021/ja405196f.s001