Jeon, Ju-eun Liao, Lijuan Kim, Heegyu Sim, Chung J. Oh, Dong-Chan Oh, Ki-Bong Shin, Jongheon Cytotoxic Diterpenoid Pseudodimers from the Korean Sponge <i>Phorbas gukhulensis</i> Four new cytotoxic diterpenoid pseudodimers (<b>2</b>–<b>5</b>), along with a previously reported one, gukulenin A (<b>1</b>), were isolated from the marine sponge <i>Phorbas gukhulensis</i> collected off the coast of Gagu-do, Korea. These novel compounds, designated gukulenins C–F (<b>2</b>–<b>5</b>), were determined by extensive spectroscopic analyses to be pseudodimers of the gagunins, like gukulenin A. The termini of the tropolone-containing side chains in gukulenins C–E (<b>2</b>–<b>4</b>) were found to have diverse modifications involving acetamides or taurine, whereas gukulenin F (<b>5</b>) was formed from <b>1</b> by the ring-opening of a cyclic hemiketal. The relative and absolute configurations were assigned by Murata’s and modified Snatzke’s methods using a HETLOC experiment and a CD measurement of a dimolybdenum complex, respectively. All of these compounds exhibited significant cytotoxicity against the K562 and A549 cell lines. marine sponge Phorbas gukhulensis;cyclic hemiketal;Cytotoxic Diterpenoid Pseudodimers;gukulenin;novel compounds;Korean Sponge Phorbas gukhulensisFour;pseudodimer;K 562;HETLOC experiment;spectroscopic analyses;CD measurement;549 cell lines 2016-02-18
    https://acs.figshare.com/articles/journal_contribution/Cytotoxic_Diterpenoid_Pseudodimers_from_the_Korean_Sponge_i_Phorbas_gukhulensis_i_/2372656
10.1021/np400389c.s001