10.1021/cs400591u.s001 Dan Huang Dan Huang Xuejian Li Xuejian Li Fangxi Xu Fangxi Xu Luhang Li Luhang Li Xufeng Lin Xufeng Lin Highly Enantioselective Synthesis of Dihydroquinazolinones Catalyzed by SPINOL-Phosphoric Acids American Chemical Society 2016 sequence Dihydroquinazolinones Catalyzed AcidsThe spirocyclic acid cascade reactions aldehyde ortho substituent dihydroquinazolinone ee aminobenzamide condensation chiral stereocontrol yield enantioselective organocatalyst room temperature Enantioselective Synthesis 2016-02-18 17:59:39 Journal contribution https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Synthesis_of_Dihydroquinazolinones_Catalyzed_by_SPINOL_Phosphoric_Acids/2369965 The asymmetric condensation/amine addition cascade sequence of 2-aminobenzamides and aldehydes catalyzed by chiral spirocyclic SPINOL-phosphoric acids was realized. SPINOL-phosphoric acid <b>1j</b> was found to be a general, highly enantioselective organocatalyst for such cascade reactions at room temperature, affording 2,3-dihydroquinazolinones in excellent yields (up to 99%) with good to excellent ee’s (up to 98%). The best level of stereocontrol was obtained for aromatic aldehydes with an ortho substituent.