10.1021/ol402728y.s001 Sushobhan Chowdhury Sushobhan Chowdhury Tanmoy Chanda Tanmoy Chanda Suvajit Koley Suvajit Koley B. Janaki Ramulu B. Janaki Ramulu Raymond C. F. Jones Raymond C. F. Jones Maya Shankar Singh Maya Shankar Singh Palladium Catalyzed Oxidative Coupling of α‑Enolic Dithioesters: A New Entry to 3,4,5-Trisubstituted 1,2-Dithioles <i>via</i> a Double Activation Strategy American Chemical Society 2013 dithiole insight catalyze Pd Optimization data Dithioester substrate scope palladium Trisubstituted Enolic method New Entry dithioester activation trisubstituted construction formation enolic Dithiole Double Activation StrategyAn cascade Palladium Catalyzed Oxidative cleavage bond 2013-10-18 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Palladium_Catalyzed_Oxidative_Coupling_of_Enolic_Dithioesters_A_New_Entry_to_3_4_5_Trisubstituted_1_2_Dithioles_i_via_i_a_Double_Activation_Strategy/2365450 An operationally simple, facile, and convenient one-pot straightforward method for the construction of 3,4,5-trisubstituted 1,2-dithioles has been explored and developed via palladium catalyzed self-coupling of α-enolic dithioesters for the first time. Pd(0) efficiently catalyzes the activation and cleavage of S–H and C–S bonds to achieve cascade coupling, which results in the concomitant formation of new S–S and C–C bonds. Optimization data, substrate scope, and mechanistic insights are discussed.