10.1021/ol402728y.s001
Sushobhan Chowdhury
Sushobhan
Chowdhury
Tanmoy Chanda
Tanmoy
Chanda
Suvajit Koley
Suvajit
Koley
B. Janaki Ramulu
B. Janaki
Ramulu
Raymond C. F. Jones
Raymond
C. F. Jones
Maya Shankar Singh
Maya Shankar
Singh
Palladium Catalyzed Oxidative Coupling of α‑Enolic Dithioesters: A New Entry to 3,4,5-Trisubstituted 1,2-Dithioles <i>via</i> a Double Activation Strategy
American Chemical Society
2013
dithiole
insight
catalyze
Pd
Optimization data
Dithioester
substrate scope
palladium
Trisubstituted
Enolic
method
New Entry
dithioester
activation
trisubstituted
construction
formation
enolic
Dithiole
Double Activation StrategyAn
cascade
Palladium Catalyzed Oxidative
cleavage
bond
2013-10-18 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Palladium_Catalyzed_Oxidative_Coupling_of_Enolic_Dithioesters_A_New_Entry_to_3_4_5_Trisubstituted_1_2_Dithioles_i_via_i_a_Double_Activation_Strategy/2365450
An operationally simple, facile, and convenient one-pot straightforward method for the construction of 3,4,5-trisubstituted 1,2-dithioles has been explored and developed via palladium catalyzed self-coupling of α-enolic dithioesters for the first time. Pd(0) efficiently catalyzes the activation and cleavage of S–H and C–S bonds to achieve cascade coupling, which results in the concomitant formation of new S–S and C–C bonds. Optimization data, substrate scope, and mechanistic insights are discussed.