10.1021/cm402614k.s001 Yi-Ting Chiang Yi-Ting Chiang Yung-Ting Cheng Yung-Ting Cheng Chih-Yang Lu Chih-Yang Lu Yu-Wei Yen Yu-Wei Yen Lu-Yi Yu Lu-Yi Yu Kun-Siou Yu Kun-Siou Yu Sih-Ying Lyu Sih-Ying Lyu Chieh-Yu Yang Chieh-Yu Yang Chun-Liang Lo Chun-Liang Lo Polymer–Liposome Complexes with a Functional Hydrogen-Bond Cross-Linker for Preventing Protein Adsorption and Improving Tumor Accumulation American Chemical Society 2013 cancer therapy tumor ECM environment HCT 116 colon cancer cells HSA Preventing Protein Adsorption HCT 116 tumor accumulation Tumor AccumulationTo Experimental results show stealth liposomes organ distribution problems uptake efficiency 2013-11-12 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Polymer_Liposome_Complexes_with_a_Functional_Hydrogen_Bond_Cross_Linker_for_Preventing_Protein_Adsorption_and_Improving_Tumor_Accumulation/2354863 To solve biostability and organ distribution problems in polymer-coated liposomes, this study developed tumor–extracellular matrix pH-induced targeting polymer–liposome complexes (ECM-targeting liposomes) that are highly stable in a protein-rich environment and can trigger targeting ability in tumor ECM environment. Experimental results show that the ECM-targeting liposomes significantly reduced adsorption of various proteins (HSA, IgG, and fibrinogen) and leakage of encapsulated drug doxorubicin–hydrochloride from liposomes, significantly improved uptake efficiency in HCT116 colon cancer cells, improved HCT116 tumor accumulation, and reduced distribution in normal organs (e.g., liver, spleen, lung, etc.). We demonstrate that ECM-targeting liposomes overcome the limitations of conventional liposomes and stealth liposomes in cancer therapy.