10.1021/cm402614k.s001
Yi-Ting Chiang
Yi-Ting
Chiang
Yung-Ting Cheng
Yung-Ting
Cheng
Chih-Yang Lu
Chih-Yang
Lu
Yu-Wei Yen
Yu-Wei
Yen
Lu-Yi Yu
Lu-Yi
Yu
Kun-Siou Yu
Kun-Siou
Yu
Sih-Ying Lyu
Sih-Ying
Lyu
Chieh-Yu Yang
Chieh-Yu
Yang
Chun-Liang Lo
Chun-Liang
Lo
Polymer–Liposome Complexes with a Functional
Hydrogen-Bond Cross-Linker for Preventing Protein Adsorption and Improving
Tumor Accumulation
American Chemical Society
2013
cancer therapy
tumor ECM environment
HCT 116 colon cancer cells
HSA
Preventing Protein Adsorption
HCT 116 tumor accumulation
Tumor AccumulationTo
Experimental results show
stealth liposomes
organ distribution problems
uptake efficiency
2013-11-12 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Polymer_Liposome_Complexes_with_a_Functional_Hydrogen_Bond_Cross_Linker_for_Preventing_Protein_Adsorption_and_Improving_Tumor_Accumulation/2354863
To
solve biostability and organ distribution problems in polymer-coated
liposomes, this study developed tumor–extracellular matrix
pH-induced targeting polymer–liposome complexes (ECM-targeting
liposomes) that are highly stable in a protein-rich environment and
can trigger targeting ability in tumor ECM environment. Experimental
results show that the ECM-targeting liposomes significantly reduced
adsorption of various proteins (HSA, IgG, and fibrinogen) and leakage
of encapsulated drug doxorubicin–hydrochloride from liposomes,
significantly improved uptake efficiency in HCT116 colon cancer cells,
improved HCT116 tumor accumulation, and reduced distribution in normal
organs (e.g., liver, spleen, lung, etc.). We demonstrate that ECM-targeting
liposomes overcome the limitations of conventional liposomes and stealth
liposomes in cancer therapy.