Copper-Mediated Selective C–H Activation and Cross-Dehydrogenative C–N Coupling of 2′‑Aminoacetophenones Andivelu Ilangovan Gandhesiri Satish 10.1021/ol402750r.s001 https://acs.figshare.com/articles/journal_contribution/Copper_Mediated_Selective_C_H_Activation_and_Cross_Dehydrogenative_C_N_Coupling_of_2_Aminoacetophenones/2352928 Isatins were obtained by cross-dehydrogenative C–N annulation and dealkylative C–N annulation of 2′-<i>N</i>-aryl/alkylaminoacetophenones and 2′-<i>N</i>,<i>N</i>-dialkylaminoacetophenones respectively in the presence of Cu(OAc)<sub><i>2</i></sub>·H<sub>2</sub>O/NaOAc/air. However, on reaction with CuBr, 2′-<i>N</i>-benzylaminoacetophenones underwent selective oxidation of an α-methylene group of amine rather than the 2-acetyl group to provide corresponding benzamides exclusively. Base played an important role in selective oxidation by lowering the temperature and time. 2013-11-15 00:00:00 presence dealkylative amine methylene Activation annulation oxidation role acetyl CuBr AminoacetophenonesIsatin Cu benzamide