Reigoselective Arylation of Thiazole Derivatives at 5‑Position via Pd Catalysis under Ligand-Free Conditions Xiang-Wei Liu Jiang-Ling Shi Jia-Xuan Yan Jiang-Bo Wei Kun Peng Le Dai Chen-Guang Li Bi-Qin Wang Zhang-Jie Shi 10.1021/ol4027073.s001 https://acs.figshare.com/articles/journal_contribution/Reigoselective_Arylation_of_Thiazole_Derivatives_at_5_Position_via_Pd_Catalysis_under_Ligand_Free_Conditions/2352898 An efficient regioselective arylation of thiazole derivatives <i>via</i> Pd-catalyzed C–H activation is reported. The transformation was hypothesized through a Pd(0/II) catalytic cycle in the absence of special ligand sets. This method provided an efficient process to direct arylation of thiazoles at the 5-position. 2013-11-15 00:00:00 Thiazole Derivatives ligand sets regioselective arylation ConditionsAn absence transformation Reigoselective Arylation activation Pd Catalysis method thiazole derivatives