10.1021/jo401967a.s003
José A. Gálvez
José A.
Gálvez
María D. Díaz-de-Villegas
María D.
Díaz-de-Villegas
Miriam Alías
Miriam
Alías
Ramón Badorrey
Ramón
Badorrey
Chiral Iminoesters Derived
from d‑Glyceraldehyde
in [3 + 2] Cycloaddition Reactions. Asymmetric Synthesis of a Key
Intermediate in the Synthesis of Neuramidinase Inhibitors
American Chemical Society
2013
Key Intermediate
cycloaddition
synthesis
Neuramidinase
chiral iminoesters
reaction diastereoselectively
approach
pyrrolidine influenza neuramidinase inhibitors
Asymmetric Synthesis
Chiral Iminoesters Derived
functionalized pyrrolidines
acrylate
Cycloaddition
2013-11-15 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Chiral_Iminoesters_Derived_from_d_Glyceraldehyde_in_3_2_Cycloaddition_Reactions_Asymmetric_Synthesis_of_a_Key_Intermediate_in_the_Synthesis_of_Neuramidinase_Inhibitors/2352706
Silver-catalyzed <i>endo</i>-selective and copper-catalyzed <i>exo</i>-selective asymmetric
[3 + 2] cycloadditions of acrylates
to chiral iminoesters derived from d-glyceraldehyde have
been investigated. The reaction diastereoselectively provides highly
functionalized pyrrolidines. This approach was used to develop the
first asymmetric synthesis of a key intermediate in the synthesis
of pyrrolidine influenza neuramidinase inhibitors.