Ascertaining the Suitability
of Aryl Sulfonyl Fluorides
for [<sup>18</sup>F]Radiochemistry Applications: A Systematic Investigation
using Microfluidics
Lidia Matesic
Naomi A. Wyatt
Benjamin H. Fraser
Maxine
P. Roberts
Tien Q. Pham
Ivan Greguric
10.1021/jo401759z.s001
https://acs.figshare.com/articles/journal_contribution/Ascertaining_the_Suitability_of_Aryl_Sulfonyl_Fluorides_for_sup_18_sup_F_Radiochemistry_Applications_A_Systematic_Investigation_using_Microfluidics/2352622
Optimization of [<sup>18</sup>F]radiolabeling
conditions and subsequent
stability analysis in mobile phase, PBS buffer, and rat serum of 12
aryl sulfonyl chloride precursors with various substituents (electron-withdrawing
groups, electron-donating groups, increased steric bulk, heterocyclic)
were performed using an Advion NanoTek Microfluidic Synthesis System.
A comparison of radiochemical yields and reaction times for a microfluidics
device versus a conventional reaction vessel is reported. [<sup>18</sup>F]Radiolabeling of sulfonyl chlorides in the presence of competing
nucleophiles, H-bond donors, and water was also assessed and demonstrated
the versatility and potential utility of [<sup>18</sup>F]sulfonyl
fluorides as synthons for indirect radiolabeling.
2013-11-15 00:00:00
presence
Application
synthon
radiolabeling
versatility
Suitability
reaction times
donor
utility
reaction vessel
12 aryl sulfonyl chloride precursors
Ascertaining
substituent
rat serum
steric bulk
stability analysis
phase
nucleophile
Advion NanoTek Microfluidic Synthesis System
MicrofluidicsOptimization
radiochemical yields
heterocyclic
Systematic Investigation
sulfonyl chlorides
microfluidics device
Aryl Sulfonyl Fluorides
PBS buffer
fluoride