Ascertaining the Suitability of Aryl Sulfonyl Fluorides for [<sup>18</sup>F]Radiochemistry Applications: A Systematic Investigation using Microfluidics Lidia Matesic Naomi A. Wyatt Benjamin H. Fraser Maxine P. Roberts Tien Q. Pham Ivan Greguric 10.1021/jo401759z.s001 https://acs.figshare.com/articles/journal_contribution/Ascertaining_the_Suitability_of_Aryl_Sulfonyl_Fluorides_for_sup_18_sup_F_Radiochemistry_Applications_A_Systematic_Investigation_using_Microfluidics/2352622 Optimization of [<sup>18</sup>F]­radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a conventional reaction vessel is reported. [<sup>18</sup>F]­Radiolabeling of sulfonyl chlorides in the presence of competing nucleophiles, H-bond donors, and water was also assessed and demonstrated the versatility and potential utility of [<sup>18</sup>F]­sulfonyl fluorides as synthons for indirect radiolabeling. 2013-11-15 00:00:00 presence Application synthon radiolabeling versatility Suitability reaction times donor utility reaction vessel 12 aryl sulfonyl chloride precursors Ascertaining substituent rat serum steric bulk stability analysis phase nucleophile Advion NanoTek Microfluidic Synthesis System MicrofluidicsOptimization radiochemical yields heterocyclic Systematic Investigation sulfonyl chlorides microfluidics device Aryl Sulfonyl Fluorides PBS buffer fluoride