Enantioselective Synthesis of 2‑Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate Shengbin Zhou Jiang Wang Daizong Lin Fei Zhao Hong Liu 10.1021/jo401510b.s001 https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_2_Substitued_Tetrahydroisoquinolin_1_yl_Glycine_Derivatives_via_Oxidative_Cross_Dehydrogenative_Coupling_of_Tertiary_Amines_and_Chiral_Nickel_II_Glycinate/2352604 The asymmetric synthesis of 2-substituted-tetrahydroisoquinolin-1-yl glycines was achieved by an oxidative cross-dehydrogenative coupling (CDC) reaction. This method for activation of the α-C-H bonds of amines with chiral nickel­(II) glycinate using <i>o</i>-chloranil as the sole oxidant afforded highly diastereoselective coupling adducts. The decomposition of coupling adducts readily afforded 2-substituted-tetrahydroisoquinolin-1-yl glycine derivatives. 2013-11-15 00:00:00 glycine oxidant Derivative glycinate amines derivative decomposition Oxidative GlycinateThe adduct method synthesis Chiral activation oxidative Tertiary Amines diastereoselective chiral Glycine CDC Enantioselective Synthesis bond