Enantioselective Synthesis
of 2‑Substitued-Tetrahydroisoquinolin-1-yl
Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of
Tertiary Amines and Chiral Nickel(II) Glycinate
Shengbin Zhou
Jiang Wang
Daizong Lin
Fei Zhao
Hong Liu
10.1021/jo401510b.s001
https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_2_Substitued_Tetrahydroisoquinolin_1_yl_Glycine_Derivatives_via_Oxidative_Cross_Dehydrogenative_Coupling_of_Tertiary_Amines_and_Chiral_Nickel_II_Glycinate/2352604
The
asymmetric synthesis of 2-substituted-tetrahydroisoquinolin-1-yl
glycines was achieved by an oxidative cross-dehydrogenative coupling
(CDC) reaction. This method for activation of the α-C-H bonds
of amines with chiral nickel(II) glycinate using <i>o</i>-chloranil as the sole oxidant afforded highly diastereoselective
coupling adducts. The decomposition of coupling adducts readily afforded
2-substituted-tetrahydroisoquinolin-1-yl glycine derivatives.
2013-11-15 00:00:00
glycine
oxidant
Derivative
glycinate
amines
derivative
decomposition
Oxidative
GlycinateThe
adduct
method
synthesis
Chiral
activation
oxidative
Tertiary Amines
diastereoselective
chiral
Glycine
CDC
Enantioselective Synthesis
bond