10.1021/jo401510b.s001
Shengbin Zhou
Shengbin
Zhou
Jiang Wang
Jiang
Wang
Daizong Lin
Daizong
Lin
Fei Zhao
Fei
Zhao
Hong Liu
Hong
Liu
Enantioselective Synthesis
of 2‑Substitued-Tetrahydroisoquinolin-1-yl
Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of
Tertiary Amines and Chiral Nickel(II) Glycinate
American Chemical Society
2013
glycine
oxidant
Derivative
glycinate
amines
derivative
decomposition
Oxidative
GlycinateThe
adduct
method
synthesis
Chiral
activation
oxidative
Tertiary Amines
diastereoselective
chiral
Glycine
CDC
Enantioselective Synthesis
bond
2013-11-15 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_2_Substitued_Tetrahydroisoquinolin_1_yl_Glycine_Derivatives_via_Oxidative_Cross_Dehydrogenative_Coupling_of_Tertiary_Amines_and_Chiral_Nickel_II_Glycinate/2352604
The
asymmetric synthesis of 2-substituted-tetrahydroisoquinolin-1-yl
glycines was achieved by an oxidative cross-dehydrogenative coupling
(CDC) reaction. This method for activation of the α-C-H bonds
of amines with chiral nickel(II) glycinate using <i>o</i>-chloranil as the sole oxidant afforded highly diastereoselective
coupling adducts. The decomposition of coupling adducts readily afforded
2-substituted-tetrahydroisoquinolin-1-yl glycine derivatives.