10.1021/jo401510b.s001 Shengbin Zhou Shengbin Zhou Jiang Wang Jiang Wang Daizong Lin Daizong Lin Fei Zhao Fei Zhao Hong Liu Hong Liu Enantioselective Synthesis of 2‑Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate American Chemical Society 2013 glycine oxidant Derivative glycinate amines derivative decomposition Oxidative GlycinateThe adduct method synthesis Chiral activation oxidative Tertiary Amines diastereoselective chiral Glycine CDC Enantioselective Synthesis bond 2013-11-15 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_2_Substitued_Tetrahydroisoquinolin_1_yl_Glycine_Derivatives_via_Oxidative_Cross_Dehydrogenative_Coupling_of_Tertiary_Amines_and_Chiral_Nickel_II_Glycinate/2352604 The asymmetric synthesis of 2-substituted-tetrahydroisoquinolin-1-yl glycines was achieved by an oxidative cross-dehydrogenative coupling (CDC) reaction. This method for activation of the α-C-H bonds of amines with chiral nickel­(II) glycinate using <i>o</i>-chloranil as the sole oxidant afforded highly diastereoselective coupling adducts. The decomposition of coupling adducts readily afforded 2-substituted-tetrahydroisoquinolin-1-yl glycine derivatives.