Zhou, Shengbin Wang, Jiang Lin, Daizong Zhao, Fei Liu, Hong Enantioselective Synthesis of 2‑Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate The asymmetric synthesis of 2-substituted-tetrahydroisoquinolin-1-yl glycines was achieved by an oxidative cross-dehydrogenative coupling (CDC) reaction. This method for activation of the α-C-H bonds of amines with chiral nickel­(II) glycinate using <i>o</i>-chloranil as the sole oxidant afforded highly diastereoselective coupling adducts. The decomposition of coupling adducts readily afforded 2-substituted-tetrahydroisoquinolin-1-yl glycine derivatives. glycine;oxidant;Derivative;glycinate;amines;derivative;decomposition;Oxidative;GlycinateThe;adduct;method;synthesis;Chiral;activation;oxidative;Tertiary Amines;diastereoselective;chiral;Glycine;CDC;Enantioselective Synthesis;bond 2013-11-15
    https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_2_Substitued_Tetrahydroisoquinolin_1_yl_Glycine_Derivatives_via_Oxidative_Cross_Dehydrogenative_Coupling_of_Tertiary_Amines_and_Chiral_Nickel_II_Glycinate/2352601
10.1021/jo401510b.s002