%0 Generic
%A Hashimoto, Takuya
%A Gálvez, Alberto
Osuna
%A Maruoka, Keiji
%D 2013
%T In Situ
Assembled Boronate Ester Assisted Chiral Carboxylic
Acid Catalyzed Asymmetric Trans-Aziridinations
%U https://acs.figshare.com/articles/dataset/In_Situ_Assembled_Boronate_Ester_Assisted_Chiral_Carboxylic_Acid_Catalyzed_Asymmetric_Trans_Aziridinations/2348971
%R 10.1021/ja407764u.s002
%2 https://acs.figshare.com/ndownloader/files/3987421
%K Situ Assembled Boronate Ester Assisted Chiral Carboxylic
%K chiral carboxylic acid catalyst
%K boronate ester
%K imine
%K chiral Br ønsted acid catalyst
%X We developed herein a new chiral
Brønsted acid catalyst which
is composed of two independent organic molecules, a chiral diol, and
2-boronobenzoic acid. In situ formation of a boronate ester was utilized
as a key process to generate an active catalyst. This boronate ester
assisted chiral carboxylic acid catalyst was successfully applied
to the trans-aziridination of N-Boc and N-benzyl imines with N-phenyldiazoacetamide. This
is the first catalyst to achieve high enantioselectivities using N-benzyl imines.
%I ACS Publications