%0 Journal Article
%A Tan, Lianjiang
%A Wan, Ajun
%A Li, Huili
%D 2013
%T Ag2S Quantum Dots Conjugated Chitosan Nanospheres
toward Light-Triggered Nitric Oxide Release and Near-Infrared Fluorescence
Imaging
%U https://acs.figshare.com/articles/journal_contribution/Ag_sub_2_sub_S_Quantum_Dots_Conjugated_Chitosan_Nanospheres_toward_Light_Triggered_Nitric_Oxide_Release_and_Near_Infrared_Fluorescence_Imaging/2348092
%R 10.1021/la403028j.s001
%2 https://acs.figshare.com/ndownloader/files/3986542
%K Ag 2S QDs
%K CS
%K NIR fluorescence imaging
%K NIR fluorescence
%K EDTA
%K biocompatible Ag 2S nanospheres
%K Ag 2S Quantum Dots Conjugated Chitosan Nanospheres
%K Ag 2S nanospheres
%K SNO
%K UV
%K multifunctional nanostructured materials
%K encapsulated silver sulfide quantum dots
%K NIR irradiation
%X Nanoscaled light-triggered nitric
oxide (NO) delivery vehicles
with the ability of near-infrared (NIR) fluorescence imaging was presented,
which consisted of chitosan (CS)-based S-nitrosothiols
(SNO) and encapsulated silver sulfide quantum dots (Ag2S QDs). CS-SNO compounds that bore NO-storing functional groups were
prepared via amino modification of chitosan. Water-soluble Ag2S QDs were synthesized and conjugated with the CS-SNO compounds
with the aid of ethylenediaminetetraacetic acid (EDTA). The biocompatible
Ag2S-CS-SNO nanospheres, with dimension of ∼117
nm, exhibited bright NIR fluorescence and satisfactory photostability
under NIR irradiation. The Ag2S-CS-SNO nanospheres could
release NO under irradiation of UV or visible light at physiological
pH and temperature yet would hardly release NO if NIR irradiation
was applied. Cell imaging was successfully performed, demonstrating
that the Ag2S-CS-SNO nanospheres could emit readily observable
NIR fluorescence and release NO in living cells. The NIR fluorescence
imaging of the Ag2S-CS-SNO nanospheres did not interfere
with the light-triggered NO release from them, which would provide
new perspectives for the application of multifunctional nanostructured
materials in diagnostics and imaging.
%I ACS Publications