Fontecave, Thomas Boissiere, Cedric Baccile, Niki Plou, Francisco J. Sanchez, Clement Using Evaporation-Induced Self-Assembly for the Direct Drug Templating of Therapeutic Vectors with High Loading Fractions, Tunable Drug Release, and Controlled Degradation A novel one-step approach for designing nonaggregated silica-based mesostructured therapeutic vectors is presented. Evaporation-induced self-assembly was used in combination with amphiphilic drugs for preparing already loaded class I and class II hybrid materials containing from 50 to 60 wt % (up to 75 vol %) of three drugs (glucosyl-resveratrol, stearoyl choline, sophorolipid). A good mesostructuration was able to promote an interfacial control of the drug release in PBS medium. The investigation of both release mechanisms and matrix dissolution was conducted via in situ ellipsometry and NMR. It proved that the nature of the drug/matrix interaction, the chemical composition of the drug/matrix interface, and the mesostructuration quality parameters must be taken into account at the same time for tuning the drug release rate, while maintaining the dissolution rate of silica at a reasonable level for limiting its toxicity. It proved also that noncalcined as-made silica-based class I hybrid materials can be efficiently used for tuning drug release kinetics from 1 h to day scale. stearoyl choline;class II;Tunable Drug Release;Therapeutic Vectors;chemical composition;drug release;NMR;Controlled DegradationA novel;PBS medium;mesostructuration quality parameters;matrix dissolution;High Loading Fractions;Direct Drug Templating;drug release kinetics;day scale;amphiphilic drugs;1 h;dissolution rate;release mechanisms;drug release rate 2013-12-10
    https://acs.figshare.com/articles/journal_contribution/Using_Evaporation_Induced_Self_Assembly_for_the_Direct_Drug_Templating_of_Therapeutic_Vectors_with_High_Loading_Fractions_Tunable_Drug_Release_and_Controlled_Degradation/2344621
10.1021/cm401807m.s001