10.1021/la4043638.s001
Abhishek Baral
Abhishek
Baral
Subhasish Roy
Subhasish
Roy
Ashkan Dehsorkhi
Ashkan
Dehsorkhi
Ian W. Hamley
Ian W.
Hamley
Saswat Mohapatra
Saswat
Mohapatra
Surajit Ghosh
Surajit
Ghosh
Arindam Banerjee
Arindam
Banerjee
Assembly of an Injectable Noncytotoxic Peptide-Based
Hydrogelator for Sustained Release of Drugs
American Chemical Society
2014
field emission scanning electron
gelator molecules
2 days
pH
hydrogel
vitamin B 12
peptide gelator
gel exhibits thixotropy
transmission electron
MTT assay
antibiotic vancomycin
rheometric analyses
Sustained Release
2014-01-28 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Assembly_of_an_Injectable_Noncytotoxic_Peptide_Based_Hydrogelator_for_Sustained_Release_of_Drugs/2328709
A new synthetic tripeptide-based
hydrogel has been discovered at
physiological pH and temperature. This hydrogel has been thoroughly
characterized using different techniques including field emission
scanning electron microscopic (FE-SEM) and high-resolution transmission
electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray
diffraction analyses, FT-IR, circular dichroism, and rheometric analyses.
Moreover, this gel exhibits thixotropy and injectability. This hydrogel
has been used for entrapment and sustained release of an antibiotic
vancomycin and vitamin B<sub>12</sub> at physiological pH and temperature
for about 2 days. Interestingly, MTT assay of these gelator molecules
shows almost 100% cell viability of this peptide gelator, indicating
its noncytotoxicity.