10.1021/la4043638.s001 Abhishek Baral Abhishek Baral Subhasish Roy Subhasish Roy Ashkan Dehsorkhi Ashkan Dehsorkhi Ian W. Hamley Ian W. Hamley Saswat Mohapatra Saswat Mohapatra Surajit Ghosh Surajit Ghosh Arindam Banerjee Arindam Banerjee Assembly of an Injectable Noncytotoxic Peptide-Based Hydrogelator for Sustained Release of Drugs American Chemical Society 2014 field emission scanning electron gelator molecules 2 days pH hydrogel vitamin B 12 peptide gelator gel exhibits thixotropy transmission electron MTT assay antibiotic vancomycin rheometric analyses Sustained Release 2014-01-28 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Assembly_of_an_Injectable_Noncytotoxic_Peptide_Based_Hydrogelator_for_Sustained_Release_of_Drugs/2328709 A new synthetic tripeptide-based hydrogel has been discovered at physiological pH and temperature. This hydrogel has been thoroughly characterized using different techniques including field emission scanning electron microscopic (FE-SEM) and high-resolution transmission electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray diffraction analyses, FT-IR, circular dichroism, and rheometric analyses. Moreover, this gel exhibits thixotropy and injectability. This hydrogel has been used for entrapment and sustained release of an antibiotic vancomycin and vitamin B<sub>12</sub> at physiological pH and temperature for about 2 days. Interestingly, MTT assay of these gelator molecules shows almost 100% cell viability of this peptide gelator, indicating its noncytotoxicity.