DNA “Nano-Claw”: Logic-Based Autonomous Cancer Targeting and Therapy Mingxu You Lu Peng Na Shao Liqin Zhang Liping Qiu Cheng Cui Weihong Tan 10.1021/ja4114903.s001 https://acs.figshare.com/articles/journal_contribution/DNA_Nano_Claw_Logic_Based_Autonomous_Cancer_Targeting_and_Therapy/2328295 Cell types, both healthy and diseased, can be classified by inventories of their cell-surface markers. Programmable analysis of multiple markers would enable clinicians to develop a comprehensive disease profile, leading to more accurate diagnosis and intervention. As a first step to accomplish this, we have designed a DNA-based device, called “Nano-Claw”. Combining the special structure-switching properties of DNA aptamers with toehold-mediated strand displacement reactions, this claw is capable of performing autonomous logic-based analysis of multiple cancer cell-surface markers and, in response, producing a diagnostic signal and/or targeted photodynamic therapy. We anticipate that this design can be widely applied in facilitating basic biomedical research, accurate disease diagnosis, and effective therapy. 2014-01-29 00:00:00 TherapyCell types marker disease profile photodynamic therapy DNA aptamers Programmable analysis disease diagnosis