DNA “Nano-Claw”:
Logic-Based Autonomous
Cancer Targeting and Therapy
Mingxu You
Lu Peng
Na Shao
Liqin Zhang
Liping Qiu
Cheng Cui
Weihong Tan
10.1021/ja4114903.s001
https://acs.figshare.com/articles/journal_contribution/DNA_Nano_Claw_Logic_Based_Autonomous_Cancer_Targeting_and_Therapy/2328295
Cell
types, both healthy and diseased, can be classified by inventories
of their cell-surface markers. Programmable analysis of multiple markers
would enable clinicians to develop a comprehensive disease profile,
leading to more accurate diagnosis and intervention. As a first step
to accomplish this, we have designed a DNA-based device, called “Nano-Claw”.
Combining the special structure-switching properties of DNA aptamers
with toehold-mediated strand displacement reactions, this claw is
capable of performing autonomous logic-based analysis of multiple
cancer cell-surface markers and, in response, producing a diagnostic
signal and/or targeted photodynamic therapy. We anticipate that this
design can be widely applied in facilitating basic biomedical research,
accurate disease diagnosis, and effective therapy.
2014-01-29 00:00:00
TherapyCell types
marker
disease profile
photodynamic therapy
DNA aptamers
Programmable analysis
disease diagnosis