%0 Journal Article %A Ermolenko, Ludmila %A Zhaoyu, Hu %A Lejeune, Clarisse %A Vergne, Carine %A Ratinaud, Céline %A Nguyen, Thanh Binh %A Al-Mourabit, Ali %D 2014 %T Concise synthesis of Didebromohamacanthin A and Demethylaplysinopsine: Addition of Ethylenediamine and Guanidine Derivatives to the Pyrrole-Amino Acid Diketopiperazines in Oxidative Conditions %U https://acs.figshare.com/articles/journal_contribution/Concise_synthesis_of_Didebromohamacanthin_A_and_Demethylaplysinopsine_Addition_of_Ethylenediamine_and_Guanidine_Derivatives_to_the_Pyrrole_Amino_Acid_Diketopiperazines_in_Oxidative_Conditions/2325298 %R 10.1021/ol4036177.s001 %2 https://acs.figshare.com/ndownloader/files/3962929 %K demethylaplysinopsine %K Didebromohamacanthin %K guanidine derivatives %K acid %K Concise synthesis %K Guanidine Derivatives %K methodology %K approach %K Diketopiperazine %K Ethylenediamine %K products didebromohamacanthin %K diketopiperazine %K Oxidative ConditionsOxidative nucleophilic addition %K aminoimidazolone %K basis %K ethylenediamine %K Demethylaplysinopsine %K quinoxalinone %K dihydro %X Oxidative nucleophilic addition of ethylenediamine and guanidine derivatives to pyrrole-amino acid diketopiperazines was shown to provide substituted 5,6-dihydro-2­(1H)-piperazinones, quinoxalinones, and 2-aminoimidazolones. On the basis of this methodology, a concise approach to natural products didebromohamacanthin A and demethylaplysinopsine has been demonstrated. %I ACS Publications