10.1021/ol4036159.s001 Sébastien Lethu Sébastien Lethu Shigeru Matsuoka Shigeru Matsuoka Michio Murata Michio Murata Highly Efficient Preparation of Selectively Isotope Cluster-Labeled Long Chain Fatty Acids via Two Consecutive C<sub>sp<sup>3</sup></sub>–C<sub>sp<sup>3</sup></sub> Cross-Coupling Reactions American Chemical Society 2014 Efficient Preparation Long Consecutive protein acid Csp Fatty Isotope access Selectively synthesis alkyl chain yield ReactionsAn conformation compound Such NMR interaction Acid lipidic biomolecules 2014-02-07 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Highly_Efficient_Preparation_of_Selectively_Isotope_Cluster_Labeled_Long_Chain_Fatty_Acids_via_Two_Consecutive_C_sub_sp_sup_3_sup_sub_C_sub_sp_sup_3_sup_sub_Cross_Coupling_Reactions/2325295 An efficient synthesis involving two copper-catalyzed alkyl–alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR- and IR-active compounds were obtained in excellent overall yields and will be further used for determining the conformation of an alkyl chain of lipidic biomolecules upon interaction with proteins.