10.1021/ol4036159.s001
Sébastien Lethu
Sébastien
Lethu
Shigeru Matsuoka
Shigeru
Matsuoka
Michio Murata
Michio
Murata
Highly Efficient Preparation of Selectively Isotope
Cluster-Labeled Long Chain Fatty Acids via Two Consecutive C<sub>sp<sup>3</sup></sub>–C<sub>sp<sup>3</sup></sub> Cross-Coupling Reactions
American Chemical Society
2014
Efficient Preparation
Long
Consecutive
protein
acid
Csp
Fatty
Isotope
access
Selectively
synthesis
alkyl chain
yield
ReactionsAn
conformation
compound
Such NMR
interaction
Acid
lipidic biomolecules
2014-02-07 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Highly_Efficient_Preparation_of_Selectively_Isotope_Cluster_Labeled_Long_Chain_Fatty_Acids_via_Two_Consecutive_C_sub_sp_sup_3_sup_sub_C_sub_sp_sup_3_sup_sub_Cross_Coupling_Reactions/2325295
An efficient synthesis
involving two copper-catalyzed alkyl–alkyl
coupling reactions has been designed to easily access doubly isotope-labeled
fatty acids. Such NMR- and IR-active compounds were obtained in excellent
overall yields and will be further used for determining the conformation
of an alkyl chain of lipidic biomolecules upon interaction with proteins.