Absolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers Danielle S. Meador David A. Spivak 10.1021/ol500173y.s001 https://acs.figshare.com/articles/journal_contribution/Absolute_Configuration_Determination_Using_Enantiomeric_Pairs_of_Molecularly_Imprinted_Polymers/2317069 A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as “DuoMIPs”. The ratio of HPLC capacity factors (<i>k</i>′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC. 2014-03-07 00:00:00 HPLC capacity factors DuoMIP Absolute Configuration Determination binding geometry AC Molecularly Imprinted PolymersA Enantiomeric Pairs enantiomeric pair γ factor