Absolute Configuration Determination Using Enantiomeric
Pairs of Molecularly Imprinted Polymers
Danielle
S. Meador
David A. Spivak
10.1021/ol500173y.s001
https://acs.figshare.com/articles/journal_contribution/Absolute_Configuration_Determination_Using_Enantiomeric_Pairs_of_Molecularly_Imprinted_Polymers/2317069
A new method for
determination of absolute configuration (AC) is
demonstrated using an enantiomeric pair of molecularly imprinted polymers,
referred to as “DuoMIPs”. The ratio of HPLC capacity
factors (<i>k</i>′) for the analyte on each of the
DuoMIPs is defined as the γ factor and can be used to determine
AC when above 1.2. A mnemonic based on the complementary binding geometry
of the DuoMIPs was used to aid in understanding and prediction of
AC.
2014-03-07 00:00:00
HPLC capacity factors
DuoMIP
Absolute Configuration Determination
binding geometry
AC
Molecularly Imprinted PolymersA
Enantiomeric Pairs
enantiomeric pair
γ factor